Contact | Legal | Deutsch German
Zur Startseite der Universitńt Bremen






Foto Kelm

Mr.
Prof. Dr. S├Şrge Kelm

Faculty 02
Biology/Chemistry Biology/Chemistry

E-Mail: skelm@uni-bremen.de

Affiliations | Research Topics | Cooperations | Projects | Scientific Activities | Resources


Affiliations


Research Topics
Life sciences
» Basic Biological and Medical Research
» Microbiology, Virology and Immunology
Natural sciences
» Biological Chemistry and Food Chemistry


Cooperations

Researchers with cooperation
Institution City Category Country of origin
Prof. Beat Ernst / Universit├Ąt Basel Basel University abroad
Prof. Mark von Itzstein / Griffith University Gold Coast University abroad
Prof. Paul Crocker / University Dundee Dundee University abroad
Prof. Kathrin M├Ądler / Universit├Ąt Bremen Bremen University Germany
Prof. Lars Nitschke / Universit├Ąt Erlangen Erlangen University Germany
Prof. Jonathan Andrew Nok / Ahmadu Bello University Zaria University abroad
Prof. Mohammed M. Mamman / Nigerian Institute for Trypanosomiasis Research Kaduna Research Center abroad
Prof. Daniel Achukwi / IRAD Yaounde Research Center abroad
Dr. Antje Hebestreit / BIPS Bremen Leibniz Association
Prof. Wolfgang Ahrens / BIPS Bremen Leibniz Association
Prof. Ralf Dringen / Universit├Ąt Bremen Bremen University Germany
Prof. Siva Kumar Nadimpalli /University Hyderabad Hyderabad University abroad
Dr. Martin K Wild / MPI Molekulare Biomedizin M├╝nster Max Planck Society
Prof. Ulrich Kulozik / TU M├╝nchen Weihenstephan University Germany
Dr Izabella Brand / Universit├Ąt Oldenburg Oldenburg University Germany
Prof. Bernd Meyer / Universit├Ąt Hamburg Hamburg University Germany
Prof. Thomas Peters / Universit├Ąt L├╝beck L├╝beck University Germany
Prof. Makoto Kiso / Gifu University Gifu University abroad



Projects

Most significant projects
Code Indication deutsch Indication englisch Cooperation partners Funding sources/agencies Term
Bestimmung bioaktiver Glycoverbindungen Innovative Verfahren zur Bestimmung und Anreicherung bioaktiver Glykoverbindungen aus Milch f├╝r die Entwicklung von prebiotischen Lebensmitteln Innovative process for the detection and enrichment of biologically active glycocompounds from milk for the develpoment of prebiotic food GALAB Technologies GmbH Milupa GmbH, Numico Research Germany Technische Universit├Ąt M├╝nchen, Lehrstuhl f├╝r Lebensmittelverfahrenstechnik und Molkereitechnologie Drittmittel: BMBF, GALAB 2005 - 2008
Siglecs bei Virusinfektionen Die Rolle von Siglecs bei Virusinfektionen The role of siglecs in viral infections Prof. Reinhard Brossmer, Universit├Ąt Heidelberg Prof. Lars Nitschke, Universit├Ąt Erlangen Prof. Thomas Peters, Universit├Ąt L├╝beck Prof. Bernd Meyer, Universit├Ąt Hamburg Prof. Beat Ernst, Universit├Ąt Basel, Schweiz Prof. Nicolai Bovin, Shemiakin-Insti Drittmittel: T├Ânjes-Vagt-Stiftung 2005 - 2009
Charakterisierung von Trans-Sialidase Expression und Charakterisierung rekombinanter Trans-Sialidase aus Trypanosoma congolense Expression and characterization of recombinant trans-sialidase from Trypanosoma congolense Prof. A.J. Nok, Zaria, Nigeria Drittmittel: DFG Fa. Milupa 2005 - 2010
Sialylierung von Glykokonjugaten Funktionen und Modifikationen sialylierter Milch-Glykokonjugate Functions and modifications of sialylated milk glycoconjugates Milupa Research, Friedrichsdorf Drittmittel: Milupa Research, Friedrichsdorf 2004 - 2005
Wechselwirkung des Siglecs CD22 Wechselwirkung des Siglecs CD22 mit Glykokonjugaten und resultierende biologische Funktionen Interaction of Siglec-2 (CD22) with glycoconjugates and resulting biological functions Prof. Nitschke, Lars, Universit├Ąt Erlangen Milupa Research, Friedrichsdorf Drittmittel: Zentrum f├╝r Biotechnologie und Ern├Ąhrung 2003 - 2004
MAG interactions with sialylated ligands Konformationelle Kontrolle der Pr├Ąsentation von geladenen, hydrophilen und hydrophoben Gruppen bei Kohlenhydrat-MAG Interaktionen im zentralen Nervensystem Conformational control of the presentation of charged, hydrophilic, and hydrophobic groups in carbohydrate-MAG interactions in the central nervous system Beat Ernst, Basel Bernd Meyer, Hamburg (Koordinator) Thomas Peters, L├╝beck Drittmittel: Volkswagenstiftung 2001 - 2009
Evolution der Sialylierung Klonierung und Charakterisierung von Siglecs und Sialyltransferasen aus Fischen und Echinodermanten Cloning and characterisation of siglces and sialyltransferases from fish and echinoderms Universit├Ąt Bremen 2001 - 2004
Modifikation von HDGF Post-translationale Modifikationen von Hepatoma-derived Growth Factor und verwandten Proteinen Post-translational modification of hepatoma-derived growth factor and related proteins Universit├Ąt Bremen 2001 - 2010
Bindungspartner von MAG Isolierung und Charakterisierung neuronaler Bindungspartner des Myelin-assoziierten Glykoproteins Isolation and Characterisation of neuronal binding partners of the myelin-associated glycoprotein (MAG) Reinhard Brossmer Melitta Schachner Drittmittel: Deutsche Forschungsgemeinschaft 1999 - 2002
Molecular recognition by siglecs Molekulare Erkennungsmechanismen bei Siglecs Molecular recognition of sialylated ligands by sialoadhesin and related proteins Reinhard Brossmer, Heidelberg Paul R. Crocker, Dundee, UK Marie Filbin, New York, USA Yvonne Jones, Oxford, UK Lars Nitschke, W├╝rzburg Anton van der Merwe, Oxford, UK Drittmittel: Human Frontier Science Program 1998 - 2001



Scientific Activities

Most significant Publications
C-4 Modified Sialosides Enhance Binding to Siglec-2 (CD22): Towards Potent Siglec Inhibitors for Immunoglycotherapy
Type
Author(s)S. Kelm, P. Madge, T. Islam, R. Bennett, H. Koliwer-Brandl, M. Waespy, M. v. Itzstein, T. Haselhorst
Year2013
InAngewandte Chemie International Edition
Year52
Issue13
Pages3616ÔÇô3620
Doi10.1002/anie.201207267
Link zu VolltextLink (extern): http://http://onlinelibrary.wiley.com/doi/10.1002/anie.201207267/abstract http://http://onlinelibrary.wiley.com/doi/10.1002/anie.201207267/abstract
Monograph
 
Biochemical characterization of trans-sialidase TS1 variants from Trypanosoma congolense
Type
Author(s)H. Koliwer-Brandl, T.T. Gbem, M. Waespy, O. Reichert, P. Mandel, E. Drebitz, F. Dietz, S. Kelm
Year2011
InBMC Biochemistry
Year12
Pages39
Doi10.1186/1471-2091-12-39
Link zu VolltextLink (extern): http://http://www.biomedcentral.com/1471-2091/12/39 http://http://www.biomedcentral.com/1471-2091/12/39
Article
 
The ligand-binding domain of CD22 is needed for inhibition of the BCR signal, as demonstrated by a novel human CD22-specific inhibitor compound
Type
Author(s)S. Kelm, J. Gerlach, R. Brossmer, C. Danzer, L. Nitschke
Year2002
InJ. Exp. Med.
Year195
Issue9
Pages1207-1213
Doi10.1084/jem.20011783
Link zu VolltextLink (extern): http://http://jem.rupress.org/content/195/9/1207.abstract http://http://jem.rupress.org/content/195/9/1207.abstract
Article
 
Molecular basis for the generation in pigs of influenza A viruses with pandemic potential
Type
Author(s)T. Ito, J. N. S. S. Couceiro, S. Kelm, L. G. Baum, S. Krauss, M. R. Castrucci, I. Donatelli, H. Kida, J. C. Paulson, R. G. Webster, Y. Kawaoka
Year1998
InJ. Virol.
Year72
Issue9
Pages7367-7373
Link zu VolltextLink (extern): http://jvi.asm.org/content/72/9/7367.long http://jvi.asm.org/content/72/9/7367.long
Article
 
Sialoadhesin, MAG and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily
Type
Author(s)S. Kelm, A. Pelz, R. Schauer, M. T. Filbin, S. Tang, M.-E. de Bellard, R. L. Schnaar, J. A. Mahoney, A. Hartnell, P. Bradfield, P. R. Crocker
Year1994
InCurr. Biol.
Year4
Issue11
Pages965-972
Doi10.1016/S0960-9822(00)00220-7
Link zu VolltextLink (extern): http://www.cell.com/current-biology/abstract/S0960-9822%2800%2900220-7 http://www.cell.com/current-biology/abstract/S0960-9822%2800%2900220-7
Article
 


 


Resources
 
More information


 
Sialic acids in cellular interactions and signal transduction (sialic acid-recognising proteins;
evolution of sialic acid metabolism;
role of trans-sialidases for the transmission of Trypanosomes;
lectins in biomineralisation (perlucin).





« back